Outcome in radiographic complete regression of unresectable head and neck cancer with carotid artery encasement from induction chemotherapy followed by concurrent chemoradiotherapy: Case reports

Autor: Federico Ampil, Amol Takalkar, Guillermo Sangster, Troy Richards
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Precision Radiation Oncology, Vol 3, Iss 2, Pp 65-68 (2019)
Druh dokumentu: article
ISSN: 2398-7324
DOI: 10.1002/pro6.67
Popis: Abstract Little is known about the effects of non‐operative treatment for unresectable head and neck cancer with carotid artery encasement. While induction chemotherapy followed by concurrent chemoradiotherapy/sequential chemoradiotherapy is usually recommended for this disease entity, conclusive evidence regarding the benefit achieved from such therapeutic intervention remains sparse. The authors describe two cases of head and neck cancer with carotid artery encasement managed by induction chemotherapy followed by concurrent chemoradiotherapy, and review the literature. Despite the complete disappearance of the locally advanced tumor after the sequential chemoradiotherapy, recurrence and progression of tumor subsequently developed. The untoward event was believed to be due to the prolongation of the overall treatment time and the radiotherapy course. It is surmised that the continued use of sequential chemoradiotherapy in the management of head and neck cancer with carotid artery encasement can be justified, provided it is aggressive, timely, and without undue prolongations.
Databáze: Directory of Open Access Journals