Deep brain stimulation with short versus conventional pulse width in Parkinson's disease and essential tremor: A systematic review and meta-analysis

Autor: Sara Smeets, Alexandra Boogers, Tine Van Bogaert, Jana Peeters, Myles McLaughlin, Bart Nuttin, Tom Theys, Wim Vandenberghe, Philippe De Vloo
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Brain Stimulation, Vol 17, Iss 1, Pp 71-82 (2024)
Druh dokumentu: article
ISSN: 1935-861X
DOI: 10.1016/j.brs.2023.12.013
Popis: Background: To maximize clinical benefit and minimize stimulation-induced side effects, optimising deep brain stimulation (DBS) parameters is paramount. Recent literature suggests a potential benefit of short pulse width DBS (spDBS; ≤40 μs) over conventional pulse width DBS (cDBS; ≥60 μs) in movement disorders. Objective: To compare therapeutic window (TW), therapeutic and side effects and energy consumption of spDBS and cDBS in movement disorders. Methods: We systematically searched Medline, Embase, Cochrane Library and Web of Science. Appropriate paired analyses were performed. Results: Nine Parkinson's disease (PD) (143 patients), 4 essential tremor (ET) (26 patients) and no dystonia studies were included in the meta-analysis. TW defined as therapeutic amplitude range was larger with spDBS vs. cDBS in PD (standardized mean difference (SMD) = -1.04, p
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