Evaluation of effectiveness of solvent-detergent viral in activation in the manufacture of intravenous human immunoglobulin G in a model of virus diarrhea — mucosal disease of cattle
| Autor: | A V Kaz’yanin, N V Zubkova, I V Krasilnikov, A K Lobastova, V V Anastasiev, A M Nikolaeva, T I Glotova, O V Kungurtseva, A G Glotov |
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| Jazyk: | English<br />Russian |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | RUDN Journal of Medicine, Vol 0, Iss 4, Pp 24-30 (2013) |
| Druh dokumentu: | article |
| ISSN: | 2313-0245 2313-0261 |
| Popis: | In model experiments using in vitro virus diarrhea — mucosal disease in cattle (bovine VD-MDC) studied the effectiveness of solvent-detergent (SD) virus inactivation used in the production of intravenous human immunoglobulin G (IgG). Optimized conditions for SD processing of immunoglobulin: the final concentration of tributylphosphate (TBP) 0.3% 0.2% sodium cholate, process temperature of 30 ± 1 °C to 36 ± 1 °C, incubation time 6 hours. The level of reduction of VD-MDC in the processing of the drug in these conditions was more than 6 log 10 TCD 50/ml. |
| Databáze: | Directory of Open Access Journals |
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