Base-controlled annulation of tryptamine-derived isocyanides with nitrile imines for access to polycyclic spiroindoline derivatives

Autor: Xiaofeng Wang, Luorong Yuan, Xiaoping Xu, Shunjun Ji
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Green Synthesis and Catalysis, Vol 4, Iss 2, Pp 181-185 (2023)
Druh dokumentu: article
ISSN: 2666-5549
DOI: 10.1016/j.gresc.2022.06.001
Popis: An annulation reaction of tryptamine-derived isocyanides with hydrazonyl chlorides in the presence of bases was developed. Controlled by different bases, [1+ ​2+3] annulation and [1+ ​2+3]/[2 ​+ ​3] annulation cascade were realized. In the latter reaction, five new chemical bonds as well as three new heterocycles were formed in one step. It showed extremely high efficiency, relatively broad substrate scope, milder reaction conditions, good tolerance of functional groups and good chemoselectivity.
Databáze: Directory of Open Access Journals