Very early MRI responses to therapy as a predictor of later radiographic progression in early rheumatoid arthritis

Autor: Philip G. Conaghan, Mikkel Østergaard, Orrin Troum, Michael A. Bowes, Gwenael Guillard, Bethanie Wilkinson, Zhiyong Xie, John Andrews, Amy Stein, Douglass Chapman, Andrew Koenig
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-6 (2019)
Druh dokumentu: article
ISSN: 1478-6362
DOI: 10.1186/s13075-019-2000-1
Popis: Abstract Background The objective of this study was to evaluate early changes in magnetic resonance imaging (MRI) and clinical disease activity measures as predictors of later structural progression in early rheumatoid arthritis (RA). Methods This was a post hoc analysis of data pooled across treatments from a three-arm (tofacitinib monotherapy, tofacitinib with methotrexate [MTX], or MTX monotherapy) trial of MTX-naïve patients with early, active RA. Synovitis, osteitis and erosions were assessed with the Outcome Measures in Rheumatology (OMERACT) RA MRI scoring system (RAMRIS) and RAMRIQ (automated quantitative RA MRI assessment system; automated RAMRIS) at months 0, 1, 3, 6 and 12. Radiographs were assessed at months 0, 6 and 12, and clinical endpoints were assessed at all timepoints. Univariate and multivariate analyses explored the predictive value of early changes in RAMRIS/RAMRIQ parameters and disease activity measures, with respect to subsequent radiographic progression. Results Data from 109 patients with a mean RA duration of 0.7 years were included. In univariate analyses, changes in RAMRIS erosions at months 1 and 3 significantly predicted radiographic progression at month 12 (both p
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