Clinical Features and Biomarkers for Early Prediction of Refractory Mycoplasma Pneumoniae Pneumonia in Children

Autor: Qin Chen, Tingting Hu, Ling Wu, Lumin Chen
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Emergency Medicine International, Vol 2024 (2024)
Druh dokumentu: article
ISSN: 2090-2859
DOI: 10.1155/2024/9328177
Popis: Summary of Background Data.With the increasing incidence and mortality of refractory mycoplasma pneumonia (RMPP), the early diagnosis and treatment of RMPP have attracted more and more attention and have become a major concern in pediatrics. Objective. The study aimed to analyze the clinical characteristics of children with RMPP and to explore the biomarkers for the early prediction of RMPP, thus providing references for the clinical diagnosis and treatment of RMPP in children. Methods. Baseline clinical characteristics, clinical symptoms, physical examination, chest imaging, and laboratory indicators between children with RMPP and general refractory mycoplasma pneumoniae pneumonia (GMPP) were compared. Multiple logistic regression analysis was used to determine independent risk factors for RMPP. ROC curves were adopted to analyze the predictive values of biomarkers. Results. The RMPP group had more severe clinical symptoms and manifestations on imaging (including pleural effusion, pulmonary consolidation, and pulmonary atelectasis), a higher incidence of extrapulmonary complications, and a longer duration of hospital stays. Results of multiple logistic regression analysis showed that serum D-dimer (OR = 8.169, P
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