Lugol Increases Lipolysis through Upregulation of PPAR-Gamma and Downregulation of C/EBP-Alpha in Mature 3T3-L1 Adipocytes

Autor: Cuellar-Rufino Sergio, Zepeda Rossana Citlali, Flores-Muñoz Mónica, Santiago-Roque Isela, Arroyo-Helguera Omar
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Nutrition and Metabolism, Vol 2020 (2020)
Druh dokumentu: article
ISSN: 2090-0724
2090-0732
DOI: 10.1155/2020/2302795
Popis: Overweight and obesity are defined as excessive and abnormal fat accumulation that is harmful to health. This study analyzes the effect of different concentrations of the lugol solution (molecular iodine dissolved in potassium iodide) on lipolysis in cultured 3T3-L1-differentiated adipocytes. The mature adipocytes were treated with doses from 1 to 100 µm of lugol for 0.5, 6, and 24 h. The results showed that mature adipocytes exposed to lugol decrease their viability and increase caspase-3 activity with a lethal dose (LD50) of 473 µm. In mature adipocytes, lugol decreased the total intracellular lipid content, being significant at doses of 10 and 100 µm after 6 and 24 h of treatment (P
Databáze: Directory of Open Access Journals
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