Topiramate Versus Valproate Sodium as Adjunctive Therapies to a Combination of Lithium and Risperidone for Adolescents with Bipolar I Disorder: Effects on Weight and Serum Lipid Profiles
Autor: | Javad Alaghband-Rad, Mehdi Tehrani-Doost, Mohammad Reza Mohammadi, Toktam Faghihi, Zahra Shahrivar, Javad Mahmoudi-Gharaei, Padideh Ghaeli |
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Jazyk: | angličtina |
Rok vydání: | 2012 |
Předmět: | |
Zdroj: | Iranian Journal of Psychiatry, Vol 7, Iss 1, Pp 1-10 (2012) |
Druh dokumentu: | article |
ISSN: | 1735-4587 2008-2215 |
Popis: | Objective: To compare the effects of topiramate versus valproate sodium as an add-on therapy to a combination of lithium and risperidone (Li+Ris) on body weight and serum lipid profile in children and adolescents with bipolar disorder. Methods: In a single-blind randomized clinical trial, thirty children and adolescents with bipolar disorder type I in the manic or mixed phase ,treated with the combination of Li+Ris at therapeutic doses for at least 4 weeks who had the indication of add-on therapy due to a recurrent episode; a partial response or non response in the current episode or relapse were included. Participants were randomly assigned to receive either topiramate or sodium valproate as the third drug add-on therapy for a total of 6 weeks. Weight, height and serum lipid profiles were determined at baseline and at the end of week 6. Results: Differences in the mean levels of lipid profiles at baseline and after week 6 evaluation were not significant in both treatment groups. BMI z-score increased in both treatment groups, being significant only in the Li+Ris/Valproate group, increasing from (mean ±SD) 0.38 ±0.55 to 0.72 ±1.23 (p |
Databáze: | Directory of Open Access Journals |
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