| Autor: |
Rodney Lacret, Daniel Oves-Costales, Cristina Gómez, Caridad Díaz, Mercedes de la Cruz, Ignacio Pérez-Victoria, Francisca Vicente, Olga Genilloud, Fernando Reyes |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Marine Drugs, Vol 13, Iss 1, Pp 128-140 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1660-3397 |
| DOI: |
10.3390/md13010128 |
| Popis: |
A bioassay guided fractionation of the ethyl acetate extract from culture broths of the strain Streptomyces zhaozhouensis CA-185989 led to the isolation of three new polycyclic tetramic acid macrolactams (1–3) and four known compounds. All the new compounds were structurally related to the known Streptomyces metabolite ikarugamycin (4). Their structural elucidation was accomplished using a combination of electrospray-time of flight mass spectrometry (ESI-TOF MS) and 1D and 2D NMR analyses. Compounds 1–3 showed antifungal activity against Aspergillus fumigatus, Candida albicans and antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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