Correction of Clcn1 alternative splicing reverses muscle fiber type transition in mice with myotonic dystrophy

Autor: Ningyan Hu, Eunjoo Kim, Layal Antoury, Thurman M. Wheeler
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-023-37619-1
Popis: In a double homozygous mouse model of myotonic dystrophy type 1, Hu et al. use antisense oligonucleotide correction of myotonia to induce a therapeutic shift from an overabundance of oxidative muscle fibers to mechanically stronger glycolytic fibers.
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