Identification of a modulator of the actin cytoskeleton, mitochondria, nutrient metabolism and lifespan in yeast

Autor: Cierra N. Sing, Enrique J. Garcia, Thomas G. Lipkin, Thomas M. Huckaba, Catherine A. Tsang, Arielle C. Coughlin, Emily J. Yang, Istvan R. Boldogh, Ryo Higuchi-Sanabria, Liza A. Pon
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-30045-9
Popis: Actin cables affect lifespan by supporting movement and inheritance of fitter mitochondria to daughter cells in yeast. Here the authors show that branched-chain amino acid (BCAA) levels affect actin cable stability and a role for YKL075C/AAN1 in control of BCAA metabolism and actin cable stability and function.
Databáze: Directory of Open Access Journals