Effect of Letrozole, Berberine, or Their Combination for Infertility in Women with Polycystic Ovary Syndrome: Statistical Analysis Plan for a Multicenter Randomized Controlled Trial

Autor: Hong-Li Ma, Jing-Shu Gao, Feng Tian, Ernest HY Ng, Xiao-Ke Wu, Jian-Ping Liu
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: World Journal of Traditional Chinese Medicine, Vol 2, Iss 3, Pp 36-42 (2016)
Druh dokumentu: article
ISSN: 2311-8571
DOI: 10.15806/j.issn.2311-8571.2016.0009
Popis: Introduction: Letrozole showed higher ovulation and live birth rates than clomiphene in infertile women with polycystic ovary syndrome (PCOS). Berberine, a major active component of Chinese herbal medicine rhizomacoptidis, has been used to improve insulin resistance to facilitate ovulation induction in women with PCOS, but there is no study reporting the live birth or its potential as a complementary treatment to letrozole. We aim to determine the efficacy of letrozole with or without berberine in achieving live births among 644 infertile women with PCOS in Mainland China.
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