Composite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape

Autor: Jonathan Sulc, Anthony Sonrel, Ninon Mounier, Chiara Auwerx, Eirini Marouli, Liza Darrous, Bogdan Draganski, Tuomas O. Kilpeläinen, Peter Joshi, Ruth J. F. Loos, Zoltán Kutalik
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-021-02550-y
Popis: Jonathan Sulc et al. use principal component analysis and Mendelian randomization to conduct a comprehensive analysis of 14 body morphology metrics using data from the UK Biobank. Their results suggest that body size and adiposity have distinct impacts on obesity-related outcomes and highlight a BMI-neutral component affecting body fat distribution, providing further insight into the genetic basis of body shape and its consequences on human health and lifestyle.
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