| Autor: |
Paola Solis Ares, Gautam Gaur, Benjamin P. Willing, Fabian Weber, Andreas Schieber, Michael G. Gänzle |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Journal of Functional Foods, Vol 107, Iss , Pp 105643- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2023.105643 |
| Popis: |
This study aimed to determine structure–function relationships of monomeric and oligomeric flavan-3-ols (procyanidins) with respect to their antimicrobial activity and their inhibition of digestive enzymes. Monomeric flacan-3-ols were purchased as reference compounds; oligomeric procyanidins were extracted from grape seeds, separated by high-performance counter-current chromatography and characterized by LC-MS/MS. The antimicrobial activity against a broad range of intestinal microorganisms increased in the order catechin = epicatechin > epigallocatechin and oligomeric procyanidins > epigallocatechin gallate. Facultative anaerobes were highly resistant while strict anaerobes including Allobaculum sp. and Ruminococcus gnavus were 10 – 100 times more sensitive. The inhibition of digestive enzymes from the rat small intestine increased in the order catechin |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect