Estrogen receptor β promotes bladder cancer growth and invasion via alteration of miR-92a/DAB2IP signals

Autor: Zhenyu Ou, Yongjie Wang, Jinbo Chen, Le Tao, Li Zuo, Deepak Sahasrabudhe, Jean Joseph, Long Wang, Shuyuan Yeh
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Experimental and Molecular Medicine, Vol 50, Iss 11, Pp 1-11 (2018)
Druh dokumentu: article
ISSN: 1226-3613
2092-6413
DOI: 10.1038/s12276-018-0155-5
Popis: Bladder cancer: stopping the spread Blocking the effects of the female hormone estrogen may increase the survival rate of women with bladder cancer (BCa). Although BCa is more common in men, tumors are more likely to invade neighboring tissues in women. Sex hormones and their receptors, which are known to affect progression of other cancers, may play a key role. A team led by Shuyuan Yeh at the University of Rochester Medical Center, USA, and Wang Long at Central South University, Changsha, China, investigated the role that estrogen receptor beta (ERβ) plays in BCa. They found that reducing ERβ levels made BCa cells less invasive. Further investigation revealed a way to block ERβ signaling, which made BCa tumors less likely to invade neighboring tissue in a mouse model. Understanding the ERβ signaling pathway may help to develop better treatments for BCa.
Databáze: Directory of Open Access Journals
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