Biomarkers of systemic inflammation are associated with disease severity and metabolic syndrome in patients with hidradenitis suppurativaCapsule Summary

Autor: Nikolaj Holgersen, MD, Valdemar Wendelboe Nielsen, BSc, Nana Aviaaja Lippert Rosenø, MSc, Jacob P. Thyssen, MD, PhD, Alexander Egeberg, MD, PhD, Signe Holm Nielsen, MSc, PhD, Hans Christian Ring, MD, PhD, Simon Francis Thomsen, MD, PhD
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: JAAD International, Vol 15, Iss , Pp 170-178 (2024)
Druh dokumentu: article
ISSN: 2666-3287
DOI: 10.1016/j.jdin.2024.03.002
Popis: Background: Biomarkers associated with disease severity and comorbid metabolic syndrome (MetS) in patients with hidradenitis suppurativa (HS) are lacking. Objective: To identify biomarkers associated with disease severity and comorbid MetS in patients with HS. Methods: Data on hospital outpatients with HS were obtained through clinical examination and interviews. Indicators of systemic inflammation; C-reactive protein (CRP), erythrocyte sedimentation-rate (ESR), neutrophil/lymphocyte-ratio (NLR), platelet/lymphocyte-ratio (PLR), monocyte/lymphocyte-ratio (MLR), platelet/neutrophil-ratio (PNR), pan-immune-inflammation-value (PIV), and systemic-immune-inflammatory-index (SII), were calculated from blood samples. Results: Seven hundred patients were included; of those 444 (63.4%) and 256 (36.6%) were female and male, respectively, with a median age of 38.3 years (IQR = 27.9-51.0). Increasing CRP, ESR, NLR, PIV, and SII (P
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