Autor: |
Takehiro Kawashiri, Shiori Shimizu, Nao Shigematsu, Daisuke Kobayashi, Takao Shimazoe |
Jazyk: |
angličtina |
Rok vydání: |
2019 |
Předmět: |
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Zdroj: |
Journal of Pharmacological Sciences, Vol 140, Iss 3, Pp 291-294 (2019) |
Druh dokumentu: |
article |
ISSN: |
1347-8613 |
DOI: |
10.1016/j.jphs.2019.05.009 |
Popis: |
Oxaliplatin induces severe peripheral neuropathy. The effect of donepezil, a drug used for treatment of Alzheimer's disease, on oxaliplatin-induced peripheral neuropathy was investigated using both in vivo and in vitro models. Donepezil effectively attenuated oxaliplatin- and cisplatin-induced inhibition of neurite outgrowth in cultured PC12 cells. In a rat model, repeated oral administration of donepezil (5 times/week for 4 weeks) ameliorated oxaliplatin-induced mechanical allodynia (von Frey test) and sciatic nerve axonal degeneration. Moreover, donepezil did not inhibit the anti-tumor activity of oxaliplatin in any cultured cancer cell line. Therefore, donepezil may be useful for managing oxaliplatin-induced peripheral neuropathy. Keywords: Donepezil, Oxaliplatin, Peripheral neuropathy |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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