TWIST1 Gene expression as a biomarker for predicting primary doxorubicin resistance in breast cancer

Autor: Demir S, Müslümanoğlu MH, Müslümanoğlu M, Başaran S, Çalay ZZ, Aydıner A, Vogt U, Çakır T, Kadıoğlu H, Artan S
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Balkan Journal of Medical Genetics, Vol 22, Iss 2, Pp 25-30 (2019)
Druh dokumentu: article
ISSN: 1311-0160
DOI: 10.2478/bjmg-2019-0025
Popis: Doxorubicin is one of the most commonly used chemotherapeutic agents for adjuvant chemotherapy of breast cancer. In the studies focused on finding biomarkers to predict the response of the patients and tumors to the drugs used, the Twist transcription factor has been suggested as a candidate biomarker for predicting chemo-resistance of breast tumors. In this study, we aimed to investigate the relationship between TWIST transcription factor expression and the effectiveness of doxorubicin treatment on directly taken primary tumor samples from chemotherapy-naive breast cancer patients. Twenty-six primary breast tumor samples taken from 26 different breast cancer patients were included in this study. Adenosine triphosphate tumor chemo-sensitivity assay (ATP-TCA) has been used to determine tumor response to doxorubicin and real-time reverse-transcription polymerase chain reaction (RT-PCR) was used for analyzing the TWIST1 gene expression of tumors. There was a significant difference in TWIST gene expression between responder and non responder tumors (p
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