p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice

Autor: Pablo Bora, Lenka Gahurova, Tomáš Mašek, Andrea Hauserova, David Potěšil, Denisa Jansova, Andrej Susor, Zbyněk Zdráhal, Anna Ajduk, Martin Pospíšek, Alexander W. Bruce
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Communications Biology, Vol 4, Iss 1, Pp 1-19 (2021)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-021-02290-z
Popis: Bora et al. show that an early blastocyst window of p38-MAPK activity regulates ribosome-related gene expression, rRNA precursor processing, polysome formation, and protein translation. This study suggests a distinct role of p38-MAPKs for providing a permissive translational environment during mouse blastocyst primitive endoderm differentiation.
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