| Autor: |
Buerfent, Benedikt C., Ajendra, Jesuthas, Stamminger, Wiebke, Gondorf, Fabian, Hoerauf, Achim, Hübner, Marc P. |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
GMS Infectious Diseases, Vol 7, p Doc04 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2195-8831 |
| DOI: |
10.3205/id000044 |
| Popis: |
TGFβ is an anti-inflammatory molecule that suppresses pro-inflammatory immune responses. Previously, we demonstrated that chronic filarial infection has a beneficial impact on -induced sepsis. In the present study, we investigated whether this protective effect is dependent on TGFβ signaling and whether depletion of TGFβ before challenge alters the early course of sepsis . depletion of TGFβ before challenge did not alter levels of pro-inflammatory cytokines/chemokines and did neither increase the bacterial burden nor worsen -induced hypothermia six hours post challenge. Similarly, in the co-infection model, despite TGFβ depletion, mice infected with the filarial nematode exhibited milder -induced hypothermia, reduced bacterial load and pro-inflammatory immune responses. Thus, we conclude that TGFβ is not essentially modulating the initial pro-inflammatory phase during sepsis and that the protective effect of a chronic filarial infection against sepsis is independent of TGFβ signaling. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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