Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia

Autor:	Anastasiya Börsch, Daniel J. Ham, Nitish Mittal, Lionel A. Tintignac, Eugenia Migliavacca, Jérôme N. Feige, Markus A. Rüegg, Mihaela Zavolan
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Biology (General) QH301-705.5
Zdroj:	Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Druh dokumentu:	article
ISSN:	2399-3642
DOI:	10.1038/s42003-021-01723-z
Popis:	Anastasiya Börsch, Daniel Ham, and colleagues generated a time series of phenotypic measurements and RNA-Seq data from mouse skeletal muscle and comparatively analyzed these along comparable rat and human data, to assess the relevance of rodent models for human muscle aging. This study draws attention to the utility of phenotypic measurements in analyzing aging-related molecular data, as several measurements such as muscle mass, were better indicators of muscle health than chronological age.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/2d627932b677454c8644b2aba9b64e4a Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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