Re-assessing ZNF331 as a DNA methylation biomarker for colorectal cancer
Autor: | Hege Marie Vedeld, Arild Nesbakken, Ragnhild A. Lothe, Guro E. Lind |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: | |
Zdroj: | Clinical Epigenetics, Vol 10, Iss 1, Pp 1-4 (2018) |
Druh dokumentu: | article |
ISSN: | 1868-7075 1868-7083 |
DOI: | 10.1186/s13148-018-0503-2 |
Popis: | Abstract We have previously shown that aberrant promoter methylation of ZNF331 is a potential biomarker for colorectal cancer detection with high sensitivity (71%) and specificity (98%). This finding was recently confirmed by others, and it was additionally suggested that promoter methylation of ZNF331 was an independent prognostic biomarker for colorectal cancer (n = 146). In the current study, our initial colorectal cancer sample series was extended to include a total of 423 cancer tissue samples. Aberrant promoter methylation was found in 71% of the samples, thus repeatedly suggesting the biomarker potential of ZNF331 for detection of colorectal cancer. Furthermore, multivariate Cox’s analysis indicated a trend towards inferior overall survival for colorectal cancer patients with aberrant methylation of ZNF331. |
Databáze: | Directory of Open Access Journals |
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