Re-assessing ZNF331 as a DNA methylation biomarker for colorectal cancer

Autor:	Hege Marie Vedeld, Arild Nesbakken, Ragnhild A. Lothe, Guro E. Lind
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Colorectal cancer Diagnosis DNA methylation Prognosis ZNF331 Medicine Genetics QH426-470
Zdroj:	Clinical Epigenetics, Vol 10, Iss 1, Pp 1-4 (2018)
Druh dokumentu:	article
ISSN:	1868-7075 1868-7083
DOI:	10.1186/s13148-018-0503-2
Popis:	Abstract We have previously shown that aberrant promoter methylation of ZNF331 is a potential biomarker for colorectal cancer detection with high sensitivity (71%) and specificity (98%). This finding was recently confirmed by others, and it was additionally suggested that promoter methylation of ZNF331 was an independent prognostic biomarker for colorectal cancer (n = 146). In the current study, our initial colorectal cancer sample series was extended to include a total of 423 cancer tissue samples. Aberrant promoter methylation was found in 71% of the samples, thus repeatedly suggesting the biomarker potential of ZNF331 for detection of colorectal cancer. Furthermore, multivariate Cox’s analysis indicated a trend towards inferior overall survival for colorectal cancer patients with aberrant methylation of ZNF331.
Databáze:	Directory of Open Access Journals
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