Atypical Polycystic Kidney Disease as defined by Imaging

Autor: Ioan-Andrei Iliuta, Aung Zaw Win, Matthew B. Lanktree, Seung Heyck Lee, Marina Pourafkari, Fatemeh Nasri, Elsa Guiard, Amirreza Haghighi, Ning He, Alistair Ingram, Crystal Quist, David Hillier, Korosh Khalili, York Pei
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-022-24104-w
Popis: Abstract Using age- and height-adjusted total kidney volume, the Mayo Clinic Imaging Classification provides a validated approach to assess the risk of chronic kidney disease (CKD) progression in autosomal dominant polycystic kidney disease (ADPKD), but requires excluding patients with atypical imaging patterns, whose clinical characteristics have been poorly defined. We report an analysis of the prevalence, clinical and genetic characteristics of patients with atypical polycystic kidney disease by imaging. Patients from the extended Toronto Genetic Epidemiology Study of Polycystic Kidney Disease recruited between 2016 and 2018 completed a standardized clinical questionnaire, kidney function assessment, genetic testing, and kidney imaging by magnetic resonance or computed tomography. We compared the prevalence, clinical features, genetics, and renal prognosis of atypical versus typical polycystic kidney disease by imaging. Forty-six of the 523 (8.8%) patients displayed atypical polycystic kidney disease by imaging; they were older (55 vs. 43 years; P
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje