Influence of intersignaling crosstalk on the intracellular localization of YAP/TAZ in lung cells

Autor: I. A. Govorova, S. Y. Nikitochkina, E. A. Vorotelyak
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-15 (2024)
Druh dokumentu: article
ISSN: 1478-811X
DOI: 10.1186/s12964-024-01662-2
Popis: Abstract A cell is a dynamic system in which various processes occur simultaneously. In particular, intra- and intercellular signaling pathway crosstalk has a significant impact on a cell’s life cycle, differentiation, proliferation, growth, regeneration, and, consequently, on the normal functioning of an entire organ. Hippo signaling and YAP/TAZ nucleocytoplasmic shuttling play a pivotal role in normal development, homeostasis, and tissue regeneration, particularly in lung cells. Intersignaling communication has a significant impact on the core components of the Hippo pathway and on YAP/TAZ localization. This review describes the crosstalk between Hippo signaling and key lung signaling pathways (WNT, SHH, TGFβ, Notch, Rho, and mTOR) using lung cells as an example and highlights the remaining unanswered questions.
Databáze: Directory of Open Access Journals
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