Design, Synthesis and Characterization of Novel Isoxazole Tagged Indole Hybrid Compounds

Autor:	Al-Qawasmeh Raed A., Al-Nazer Louy A., Dawlat-Kari Sarah A., Abu-Qatouseh Luay, Sabri Salim S., AlDamen Murad A., Sinnokrot Mutasem
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	isoxazole indole click chemistry 1 3-dipolar cycloaddition alkyne copper (i) Chemistry QD1-999
Zdroj:	Open Chemistry, Vol 18, Iss 1, Pp 138-148 (2020)
Druh dokumentu:	article
ISSN:	2391-5420 20049749
DOI:	10.1515/chem-2020-0017
Popis:	Sixteen new isoxazole tagged indole compounds have been synthesized via copper (I) catalyzed click chemistry of the aryl hydroxamoyl chloride and an indole containing alkyne moiety. The chemical structure of the synthesized compounds has been established using various physicochemical techniques. X-ray single crystal analysis of Ethyl 1-((3-phenylisoxazol-5-yl) methyl)-1H-indole-2-carboxylate (8a) has been analyzed. All compounds were tested for their antibacterial and anticancer activities. The activities for the new compounds were weak against both bacterial strains and the cancer cell lines.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/2d326a200497499db87b647e526307ff Zobrazit plný text záznamu View record in DOAJ