| Autor: |
Arturo Blazquez-Navarro, Toralf Roch, Patrizia Wehler, Sviatlana Kaliszczyk, Chris Bauer, Constantin Thieme, Kamil S. Rosiewicz, Ulrik Stervbo, Moritz Anft, Petra Reinke, Christian Hugo, Panagiota Zgoura, Richard Viebahn, Timm Westhoff, Michal Or-Guil, Nina Babel |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Frontiers in Transplantation, Vol 2 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2813-2440 |
| DOI: |
10.3389/frtra.2023.1188535 |
| Popis: |
Human herpesvirus 6 (HHV-6) is a common opportunistic pathogen in kidney transplant recipients. Two distinct species of HHV-6, HHV-6A and HHV-6B, have been identified, of which the latter seems to be dominant. However, it is unclear whether they increase the likelihood of other viral reactivations. We characterized a multi-centre cohort of 93 patients along nine study visits for viral load. We tested for the following viruses: HHV-6A and HHV-6B, the herpesviruses cytomegalovirus (CMV) and Epstein-Barr virus (EBV) and the polyomavirus BK (BKV). We detected HHV-6A viral load in 48 (51.6%) patients, while the incidence of HHV-6B was much lower, being detected in 6 (6.5%) patients. The incidence of HHV-6A was higher than of BKV, CMV and EBV. HHV-6A also demonstrated higher viral loads than the rest of viruses. There was a non-significant trend of association between HHV-6A and HHV-6B as co-infection, whereas no increased incidence of other viruses among patients with HHV-6A reactivation was observed. There was no negative effect of high HHV-6A (>10,000 copies/ml) load on markers of renal graft and hepatic function or blood count twelve months post-transplant. In contrast to previously published data, our results show a clear dominance of HHV-6A in peripheral blood when compared to HHV-6B, with higher incidence and viral load levels. Despite the high HHV-6A loads observed, we did not identify any negative effects on posttransplant outcome. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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