The role of SARS-CoV-2 nucleocapsid protein in antiviral immunity and vaccine development

Autor:	Haiyun Yu, Fei Guan, Heather Miller, Jiahui Lei, Chaohong Liu
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	SARS-CoV-2 nucleocapsid inflammation cell death innate immunity adapted immunity Infectious and parasitic diseases RC109-216 Microbiology QR1-502
Zdroj:	Emerging Microbes and Infections, Vol 12, Iss 1 (2023)
Druh dokumentu:	article
ISSN:	22221751 2222-1751
DOI:	10.1080/22221751.2022.2164219
Popis:	ABSTRACTThe coronavirus disease 2019 (COVID-19) has caused enormous health risks and global economic disruption. This disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 nucleocapsid protein is a structural protein involved in viral replication and assembly. There is accumulating evidence indicating that the nucleocapsid protein is multi-functional, playing a key role in the pathogenesis of COVID-19 and antiviral immunity against SARS-CoV-2. Here, we summarize its potential application in the prevention of COVID-19, which is based on its role in inflammation, cell death, antiviral innate immunity, and antiviral adaptive immunity.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/2d119e42a6634505a2c0e52aac40f3f0 Zobrazit plný text záznamu View record in DOAJ