Hemodynamic and antiemetic effects of prophylactic hyoscine butyl-bromide during cesarean section under spinal anesthesia: a randomized controlled trial

Autor:	Mostafa Samy Abbas, Shimaa Abbas Hassan, Ahmed Mohamed Abbas, Amr Mohamed Thabet, Ahmed Mostafa Thabet, Magdy Mohammed Mahdy
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Bradycardia Cesarean section Hyoscine N-Butylbromide Spinal anesthesia Vomiting Anesthesiology RD78.3-87.3
Zdroj:	BMC Anesthesiology, Vol 22, Iss 1, Pp 1-8 (2022)
Druh dokumentu:	article
ISSN:	1471-2253
DOI:	10.1186/s12871-022-01659-9
Popis:	Abstract Background Abrupt bradycardia and hemodynamic instability during spinal anesthesia for cesarean section are not uncommon and are considered as one of the primary causes of intraoperative nausea and vomiting (IONV). We hypothesized that prophylactic use of hyoscine butyl-bromide (HBB) could improve hemodynamics and reduce IONV in parturients undergoing cesarean section. Methods A randomized, double-blind placebo-controlled trial was carried out in a tertiary university hospital, patients scheduled for elective cesarean section were equally randomized to receive either IV HBB 20 mg in 1 ml (Hyoscine group) or the same volume of 0.9% saline (Control group), one minute after spinal anesthesia. The primary endpoint was the incidence of intraoperative bradycardia (HR
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