3D culture technologies of cancer stem cells: promising ex vivo tumor models

Autor: Chengye Zhang, Zhaoting Yang, Da-Long Dong, Tae-Su Jang, Jonathan C. Knowles, Hae-Won Kim, Guang-Zhen Jin, Yanhua Xuan
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Tissue Engineering, Vol 11 (2020)
Druh dokumentu: article
ISSN: 2041-7314
20417314
DOI: 10.1177/2041731420933407
Popis: Cancer stem cells have been shown to be important in tumorigenesis processes, such as tumor growth, metastasis, and recurrence. As such, many three-dimensional models have been developed to establish an ex vivo microenvironment that cancer stem cells experience under in vivo conditions. Cancer stem cells propagating in three-dimensional culture systems show physiologically related signaling pathway profiles, gene expression, cell–matrix and cell–cell interactions, and drug resistance that reflect at least some of the tumor properties seen in vivo . Herein, we discussed the presently available Cancer stem cell three-dimensional culture models that use biomaterials and engineering tools and the biological implications of these models compared to the conventional ones.
Databáze: Directory of Open Access Journals
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