Dynamics of immune markers in different variants of post-psychotic depression after first-episode psychosis in young adult age
| Autor: | S. Zozulya, D. Tikhonov, V. Kaleda, T. Klyushnik |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | European Psychiatry, Vol 65, Pp S366-S367 (2022) |
| Druh dokumentu: | article |
| ISSN: | 0924-9338 1778-3585 |
| DOI: | 10.1192/j.eurpsy.2022.931 |
| Popis: | Introduction Research in recent decades focuses on understanding the role of the immune system in First-Episode Psychosis (FEP) at a young age. Our studies indicate that different stages of schizophrenia differ in the spectrum of inflammation markers. These indicators reflect the activity of the pathological process, using them as markers of the clinical state of patients at different stages of the disease. Objectives To assess the relationship of immune markers with the clinical features of remission in patients after FEP. Methods Fifty patients aged 15-25 years with post-psychotic depression (PD) after FEP (F20, F25) and 30 healthy men were included in the study. The follow-up period was two years. PD typological variants with positive affectivity (PA) (n=30) and negative affectivity (NA) (n=20) were distinguished. Leukocyte elastase (LE), a1-proteinase inhibitor (a1-PI) activity, and S-100B autoantibodies in plasma samples were measured. Results The increase of LE and a1-PI activity in plasma of both types of PD patients compared to controls was detected (p |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|