The R2TP chaperone complex: its involvement in snoRNP assembly and tumorigenesis
| Autor: | Kakihara Yoshito, Saeki Makio |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Biomolecular Concepts, Vol 5, Iss 6, Pp 513-520 (2014) |
| Druh dokumentu: | article |
| ISSN: | 1868-5021 1868-503X |
| DOI: | 10.1515/bmc-2014-0028 |
| Popis: | R2TP was originally identified in yeast Saccharomyces cerevisiae as Hsp90 interacting complex, and is composed of four different proteins: Rvb1, Rvb2, Tah1, and Pih1. This complex is well-conserved in eukaryotes, and is involved in many cellular processes such as snoRNP biogenesis, RNA polymerase assembly, PIKK signaling, and apoptosis. An increasing number of research related to R2TP suggests a linkage of its function with tumorigenesis. In this review, we provide an overview of several recent studies on R2TP that are related to cell proliferation and carcinogenesis, and propose a possible role of R2TP in tumorigenesis through regulating snoRNA/snoRNP biogenesis. |
| Databáze: | Directory of Open Access Journals |
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