Impaired Cerebral Vasomotor Reactivity in Alzheimer’s Disease

Autor: Fernando Gongora-Rivera, Adolfo Cordero-Perez, Alejandro Gonzalez-Aquines, Antonio Anaya-Escamilla, Eduardo Villarreal-Garza, Meztli Espinosa-Ortega, Mario C. Salinas-Carmona, Xochilt Ortiz-Jimenez
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: International Journal of Alzheimer's Disease, Vol 2018 (2018)
Druh dokumentu: article
ISSN: 2090-8024
2090-0252
DOI: 10.1155/2018/9328293
Popis: Background. Recent studies have shown that cerebral vascularity may be impaired in Alzheimer’s disease. Cerebral vasomotor reactivity could be an important biomarker for this pathology. Aims. The aim of this study was to investigate the alterations in cerebral vascular motor reactivity in Alzheimer’s disease subjects and to associate these changes with their cognitive scores. Methods. We recruited subjects with a diagnosis of Alzheimer’s disease and healthy controls. Demographic, clinical, imaging, and cognitive test were obtained. Then all participants performed a cerebral vascular motor reactivity test with 7% CO2 and cerebral blood flow velocities (CBFV) were recorded with transcranial doppler ultrasound before and after the test. Results. We recruited 45 subjects, 26 (21 female) Alzheimer’s disease participants and 19 (15 female) healthy controls. There were no differences in baseline cerebral blood flow velocities between the groups. After the cerebral vasomotor reactivity test, absolute mean difference in mean CBFV (ΔCBFV-m) was 8.70±4.14 versus 4.81±6.96 (p
Databáze: Directory of Open Access Journals
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