| Autor: |
Francis Omujal, Kibira Irene Tenda, Stephen Lutoti, Irene Kirabo, Simon Dembe Kasango, Kyeyune Grace Nambatya |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Scientific African, Vol 9, Iss , Pp e00484- (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2468-2276 |
| DOI: |
10.1016/j.sciaf.2020.e00484 |
| Popis: |
Root bark powder of Vepris nobilis Mziray (family Rutaceae) collected from Mukura Sub-county, Ngora District, Eastern Uganda, about 300 km from the Capital City Kampala was extracted with 70% ethanol. Phytochemical analyses was carried out as well as in vivo anti inflammatory animal tests. The GC–MS analysis identified 37 compounds in the extract including fatty acids (45.08%), sesquiterpenes (40.38%), furaquinoline alkaloids (10.93%), a phenylpropanoid (2.37%) and a triterpenoid (1.31%). Interestingly, it revealed that at 400 and 600 mg of extract / kg of body weight, formalin induced paw oedema in mice was inhibited much better than by 25 mg of Diclofenac sodium /kg body weight. It was concluded that ethanolic root bark extract of V. nobilis has important phytochemicals that need to be evaluated for anti-inflammatory activity as potential lead compounds for anti-inflammatory drug development. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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