| Autor: |
Kimie Nakamura, Koji Fujita, Motohisa Suzuki, Akiyoshi Kunugi, Yoshihiko Hirozane, Tomonori Kunikata, Bitoku Takahashi, Genta Narazaki, Hirofumi Kondo, Shotaro Haji, Keisuke Hirai, Yuishin Izumi |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Frontiers in Neurology, Vol 15 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1664-2295 |
| DOI: |
10.3389/fneur.2024.1418320 |
| Popis: |
BackgroundThe rate of disease progression varies widely among patients with amyotrophic lateral sclerosis (ALS). Prognostic assessment using biomarkers is highly anticipated to improve clinical trial design. We aimed to explore the cerebrospinal fluid (CSF) for prognostic biomarkers to predict future functional decline in patients with ALS.MethodsWe collected CSF samples from 64 patients with ALS and 25 disease controls. The prospective progression rate was calculated using the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) at CSF collection and in 6 months. The ALS patients were classified into slow, intermediate, and fast progression groups. We performed comprehensive proteomic analyses of the CSF samples. Factors with significant changes between slow and fast progression groups were investigated via receiver operating characteristic curve analyses. Moreover, the correlation of the CSF factors with progression rate was evaluated by multiple regression analyses.ResultsIn total, 26 proteins changed significantly (p 1.5 or |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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