| Autor: |
Shuhei A. Horiguchi, Tetsuya J. Kobayashi |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Physical Review Research, Vol 5, Iss 2, p L022052 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2643-1564 |
| DOI: |
10.1103/PhysRevResearch.5.L022052 |
| Popis: |
In multicellular systems, single-cell behaviors should be coordinated consistently with the overall population dynamics and functions. However, the interrelation between single-cell rules and the population-level goal is still elusive. In this work, we reveal that these two levels are naturally connected via a gradient flow structure of heterogeneous cellular populations and that biologically prevalent single-cell rules, such as unidirectional type switching and hierarchical order in types, emerge from this structure. We also demonstrate the gradient flow structure in a standard model of the T-cell immune response. This theoretical framework works as a basis for understanding multicellular dynamics and functions. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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