Association of endothelin-1 and cell surface adhesion molecules levels in patients with systemic sclerosis
| Autor: | Mauliūtė Monika, Rugienė Rita, Žėkas Vytautas, Bagdonaitė Loreta |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Journal of Laboratory Medicine, Vol 44, Iss 6, Pp 343-347 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2567-9430 2567-9449 |
| DOI: | 10.1515/labmed-2020-0050 |
| Popis: | Endothelin-1 (ET-1) has been implicated in the pathogenesis of inflammatory and fibrotic diseases, including systemic sclerosis. In addition to modulating vascular tone and extracellular matrix turnover, ET-1 up-regulates cell surface adhesion molecules–intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1).The aim of the study was to evaluate the diagnostic value of the detection of ET-1, VCAM-1 and ICAM-1 in the diagnosis of systemic sclerosis. |
| Databáze: | Directory of Open Access Journals |
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