| Autor: |
Huadong Yan, Amrita Vijay, Fanrong Jiang, Nanhong Zheng, Yaoren Hu, Honghua Ye, Benjamin Ollivere, Ting Cai, Ana M Valdes, Guruprasad P. Aithal |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Endocrinology, Diabetes & Metabolism, Vol 4, Iss 2, Pp n/a-n/a (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2398-9238 |
| DOI: |
10.1002/edm2.215 |
| Popis: |
Abstract Background COVID‐19 has a broad clinical spectrum. We investigated the role of serum markers measured on admission on severity as assessed at discharge and investigated those which relate to the effect of BMI on severity. Methods Clinical and laboratory data from 610 COVID‐19 cases hospitalized in the province of Zheijang, China were investigated as risk factors for severe COVID‐19 (assessed by respiratory distress) compared to mild or common forms using logistic regression methods. Biochemical markers were correlated with severity using spearman correlations, and a ROC analysis was used to determine the individual contribution of each of the biochemical markers on severity. We carried out formal mediation analyses to investigate the extent of the effect of body mass index (BMI) on COVID‐19 severity mediated by hypertension, glycemia, Lactose Dehydrogenase (LDH) at the time of hospitalization and C‐Reactive Protein levels (CRP), in units of standard deviations. Results The individual markers measured on admission contributing most strongly to prediction of COVID‐19 severity as assessed at discharge were LDH, CRP and glucose. The proportion of the effect of BMI on severity of COVID‐19 mediated by CRP, glycemia or hypertension, we find that glucose mediated 79% (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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