Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects

Autor: Mark Lucanic, W. Todd Plummer, Esteban Chen, Jailynn Harke, Anna C. Foulger, Brian Onken, Anna L. Coleman-Hulbert, Kathleen J. Dumas, Suzhen Guo, Erik Johnson, Dipa Bhaumik, Jian Xue, Anna B. Crist, Michael P. Presley, Girish Harinath, Christine A. Sedore, Manish Chamoli, Shaunak Kamat, Michelle K. Chen, Suzanne Angeli, Christina Chang, John H. Willis, Daniel Edgar, Mary Anne Royal, Elizabeth A. Chao, Shobhna Patel, Theo Garrett, Carolina Ibanez-Ventoso, June Hope, Jason L Kish, Max Guo, Gordon J. Lithgow, Monica Driscoll, Patrick C. Phillips
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms14256
Popis: Irreproducibility of biological findings is a major challenge for drug development. Here the authors examine the lifespans of 22 worm strains in three different laboratories and the effects of ten known chemicals to assess reproducibility in the face of variations in genetic background, chemical treatment and lab environment.
Databáze: Directory of Open Access Journals