Investigation of OCTA Biomarkers in Fabry Disease: A Long Term Follow-Up of Macular Vessel Area Density and Foveal Avascular Zone Metrics

Autor: Katerina Hufendiek, Migle Lindziute, Jessica Kaufeld, Ingo Volkmann, Dorothee Brockmann, Sami Hosari, Bettina Hohberger, Christian Mardin, Carsten Framme, Jan Tode, Karsten Hufendiek
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Ophthalmology and Therapy, Vol 12, Iss 5, Pp 2713-2727 (2023)
Druh dokumentu: article
ISSN: 2193-8245
2193-6528
63248999
DOI: 10.1007/s40123-023-00776-z
Popis: Abstract Introduction Retinal microvasculature is known to be altered in patients with Fabry disease (FD). We aimed to investigate the long-term changes in macular microvasculature and explore a reliable retinal biomarker for treatment monitoring in FD. Methods Prospective study of 26 eyes with FD followed up to 48 months (mean 24, range 8–48). OCT angiography (OCTA) images (2.9 × 2.9 mm) were obtained using Heidelberg Spectralis II at baseline and follow-up. Macular vessel area density (VAD, %) was measured in three layers: superficial vascular plexus (SVP), intermediate capillary plexus (ICP) and deep capillary plexus (DCP) in three peri-macular circular sectors (c1, c2, c3). Additionally, foveal avascular zone (FAZ) area (mm2) and horizontal and vertical diameters (µm) were assessed. Results VAD decreased over time in SVP, ICP (in sectors c2 and c3) and DCP (all sectors) (p
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje