Association of Neuroretinal Thinning and Microvascular Changes with Hypertension in an Older Population in Southern Italy

Autor: Alfredo Niro, Giancarlo Sborgia, Luisa Lampignano, Gianluigi Giuliani, Fabio Castellana, Roberta Zupo, Ilaria Bortone, Pasquale Puzo, Angelo Pascale, Valentina Pastore, Rosa Buonamassa, Roberta Galati, Marco Bordinone, Flavio Cassano, Chiara Griseta, Sarah Tirelli, Madia Lozupone, Vitoantonio Bevilacqua, Francesco Panza, Rodolfo Sardone, Giovanni Alessio, Francesco Boscia
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Clinical Medicine, Vol 11, Iss 4, p 1098 (2022)
Druh dokumentu: article
ISSN: 2077-0383
DOI: 10.3390/jcm11041098
Popis: Background: Retinal microvasculature assessment at capillary level may potentially aid the evaluation of early microvascular changes due to hypertension. We aimed to investigate associations between the measures obtained using optical coherence tomography (OCT) and OCT-angiography (OCT-A) and hypertension, in a southern Italian older population. Methods: We performed a cross-sectional analysis from a population-based study on 731 participants aged 65 years+ subdivided into two groups according to the presence or absence of blood hypertension without hypertensive retinopathy. The average thickness of the ganglion cell complex (GCC) and the retinal nerve fiber layer (RNFL) were measured. The foveal avascular zone area, vascular density (VD) at the macular site and of the optic nerve head (ONH) and radial peripapillary capillary (RPC) plexi were evaluated. Logistic regression was applied to assess the association of ocular measurements with hypertension. Results: GCC thickness was inversely associated with hypertension (odds ratio (OR): 0.98, 95% confidence interval (CI): 0.97–1). A rarefaction of VD of the ONH plexus at the inferior temporal sector (OR: 0.95, 95% CI: 0.91–0.99) and, conversely, a higher VD of the ONH and RPC plexi inside optic disc (OR: 1.07, 95% CI: 1.04–1.10; OR: 1.04, 95% CI: 1.02–1.06, respectively) were significantly associated with hypertension. Conclusion: A neuroretinal thinning involving GCC and a change in capillary density at the peripapillary network were related to the hypertension in older patients without hypertensive retinopathy. Assessing peripapillary retinal microvasculature using OCT-A may be a useful non-invasive approach to detect early microvascular changes due to hypertension.
Databáze: Directory of Open Access Journals
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