Binuclear Heteroleptic Ru(III) Dithiocarbamate Complexes: A Step towards Tunable Antiproliferative Agents

Autor:	Andrea E. Gallio, Leonardo Brustolin, Nicolò Pettenuzzo, Dolores Fregona
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	dithiocarbamate derivatives ruthenium anticancer complexes anticancer research antiproliferative activity Inorganic chemistry QD146-197
Zdroj:	Inorganics, Vol 10, Iss 3, p 37 (2022)
Druh dokumentu:	article
ISSN:	2304-6740
DOI:	10.3390/inorganics10030037
Popis:	Binuclear dithiocarbamate complexes of Ru(III) are promising candidates in the search for outstanding metal-based anticancer agents. While different dithiocarbamates have shown ligand-dependent cytotoxicity in homoleptic binuclear Ru(III) complexes, the properties of heteroleptic analogues with different dithiocarbamate (DTC) ligands have yet to be explored. We herein propose the introduction of heteroleptic ligands as tunable features for the development of improved ruthenium-based antiproliferative agents and report a synthetic strategy for their synthesis as well as the evaluation of the cytotoxic activity of a selection of binuclear heteroleptic Ru(III) compounds towards MDA-MB-231 and PC3 cells.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/2c9417ad22ac41549d9b641445ed082e Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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