Setd2 inactivation sensitizes lung adenocarcinoma to inhibitors of oxidative respiration and mTORC1 signaling

Autor: David M. Walter, Amy C. Gladstein, Katherine R. Doerig, Ramakrishnan Natesan, Saravana G. Baskaran, A. Andrea Gudiel, Keren M. Adler, Jonuelle O. Acosta, Douglas C. Wallace, Irfan A. Asangani, David M. Feldser
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-023-04618-3
Popis: SETD2 inactivation leads to heightened mTORC1 signaling, oxidative metabolism and protein synthesis in KRAS-driven mouse models of lung adenocarcinoma, contributing to the understanding of how SETD2 deficiency drives early and widespread tumor growth.
Databáze: Directory of Open Access Journals
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