High SPINK1 Expression Predicts Poor Prognosis and Promotes Cell Proliferation and Metastasis of Hepatocellular Carcinoma
| Autor: | Kaijun Huang, Wenxuan Xie, Shutong Wang, Qiao Li, Xiangling Wei, Bin Chen, Yunpeng Hua, Shaoqiang Li, Baogang Peng, Shunli Shen |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Journal of Investigative Surgery, Vol 34, Iss 9, Pp 1011-1020 (2021) |
| Druh dokumentu: | article |
| ISSN: | 0894-1939 1521-0553 08941939 |
| DOI: | 10.1080/08941939.2020.1728443 |
| Popis: | Background Serine protease inhibitor Kazal type I (SPINK1) is highly expressed and promotes tumor progress in different cancers. This study aimed to evaluate SPINK1’s prognostic value and its role in hepatocellular carcinoma (HCC) progress. Methods We use tissue micro-arrays containing 273 tumor and paired para-tumor tissues to evaluate SPINK1’s prognostic value in HCC. CCK8 cell proliferation assay, wound healing assays, transwell migration and invasion assays were performed to explore the effect of SPINIK1 on HCC cells. The Cancer Genome Atlas (TCGA) database and Gene set enrichment analysis (GSEA) were used to verify the prognosis value of SPINK1 in HCC and explore the underlying mechanisms. Results SPINK1 expression was significantly higher in tumor tissues than paired para-tumor tissues (P |
| Databáze: | Directory of Open Access Journals |
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