Intravenous epoprostenol therapy in the treatment of pulmonary arterial hypertension in Singapore

Autor: Jack Choo, Jonathan Yap, Aidila Ismail, Jin Shing Hon, Wen Ruan, Andrea Low, Soo Teik Lim, Ju Le Tan
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Annals, Academy of Medicine, Singapore, Vol 53, Iss 10, Pp 627-631 (2024)
Druh dokumentu: article
ISSN: 2972-4066
DOI: 10.47102/annals-acadmedsg.2024223
Popis: Pulmonary arterial hypertension (PAH) is a progressive disease characterised by significant morbidity and mortality. Intravenous (IV) epoprostenol (Veletri, Johnson & Johnson, US), a prostacyclin analogue, has been shown to improve exercise tolerance, PAH symptoms, haemodynamics and survival.1,2 However, there is a lack of data on feasibility and tolerability of this therapy in Singapore. A previous study examined the use of selexipag, an oral prostacyclin analogue, in a Singapore population.3 We aimed to describe the first Singapore experience of initiating and maintaining IV epoprostenol therapy for treating PAH patients in Singapore, and highlight the various issues and challenges encountered.
Databáze: Directory of Open Access Journals