| Autor: |
Rajeendra L. Pemathilaka, Jeremy D. Caplin, Saurabh S. Aykar, Reza Montazami, Nicole N. Hashemi |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Global Challenges, Vol 3, Iss 3, Pp n/a-n/a (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2056-6646 |
| DOI: |
10.1002/gch2.201800112 |
| Popis: |
Abstract Due to the particular structure and functionality of the placenta, most current human placenta drug testing methods are limited to animal models, conventional cell testing, and cohort/controlled testing. Previous studies have produced inconsistent results due to physiological differences between humans and animals and limited availability of human and/or animal models for controlled testing. To overcome these challenges, a placenta‐on‐a‐chip system is developed for studying the exchange of substances to and from the placenta. Caffeine transport across the placental barrier is studied because caffeine is a xenobiotic widely consumed on a daily basis. Since a fetus does not carry the enzymes that inactivate caffeine, when it crosses a placental barrier, high caffeine intake may harm the fetus, so it is important to quantify the rate of caffeine transport across the placenta. In this study, a caffeine concentration of 0.25 mg mL−1 is introduced into the maternal channel, and the resulting changes are observed over a span of 7.5 h. A steady caffeine concentration of 0.1513 mg mL−1 is reached on the maternal side after 6.5 h, and a 0.0033 mg mL−1 concentration on the fetal side is achieved after 5 h. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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