Expression of serum microRNAs, mir-182-5p, and miR-590-3p and its clinical significance in neonatal sepsis

Autor:	Soha M. Hamdy, Yomna A. Othman, Omayma O. Abdelaleem, Rehab G. Abd El-Hamid, Doaa Y. Ali
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Neonatal sepsis mir-182-5p miR-590-3p Pediatrics RJ1-570
Zdroj:	Egyptian Pediatric Association Gazette, Vol 72, Iss 1, Pp 1-9 (2024)
Druh dokumentu:	article
ISSN:	2090-9942
DOI:	10.1186/s43054-024-00260-8
Popis:	Abstract Background Neonatal sepsis is one of the life-threatening diseases. MicroRNAs are non-coding RNAs that play vital roles in various diseases. Methods This study included 50 neonates with sepsis and 60 healthy controls. RNA extraction and assessment of mir-182-5p and miR-590-3p using real-time PCR were done. Results Significant downregulation of mir-182-5p and miR-590-3p in neonates with sepsis compared with healthy neonates was observed. Positive correlations were confirmed between the expression levels of miR-182-5p and birth weight (R = 0.355, P = 0.012), RDW (R = 0.476, p =
Databáze:	Directory of Open Access Journals
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