BIOCOMPATIBLE COMPOSITES WITH LYSOZYME BASED ON POLYURETHANE UREA WITH N-VINYL PYRROLIDONE COPOLYMER FRAGMENTS, VINYL ACETATE AND VINYL ALCOHOL

Autor: K. V. Stashenko, T. V. Rudenchyk, R. A. Rozhnova, N. A. Galatenko, L. F. Narazhaiko
Jazyk: English<br />Russian<br />Ukrainian
Rok vydání: 2018
Předmět:
Zdroj: Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ, Vol 23, Iss 2(66), Pp 46-56 (2018)
Druh dokumentu: article
ISSN: 2304-0947
2414-5963
DOI: 10.18524/2304-0947.2018.2(66).132042
Popis: A series of PUS containing a N-vinylpyrrolidone-vinyl alcohol copolymer (VP-VA) copolymer with different percentages of 4,4’-diaminodiphenylmethane (DADF) to VP-VA (30:70; 50:50; 70:30) was synthesized. On the basis of synthesized PUS, a number of composite materials containing lysozyme (the content of the medicinal substance is 1 wt%) was obtained.According to IR spectroscopic studies, immobilization of lysozyme occurs due to intermolecular hydrogen bonds (physical immobilization).Variation of the content of copolymer VP-VA in the structure of the received РUS causes changes of physical-mechanical properties. It was established that with decrease in the amount of VP-VS copolymer in the structure of PUS there is an increase in strength and relative elongation at breakIt was established that samples of PUS with fragments of VP-VS in their structure, filled with lysozyme, synthesized by the percentage ratio of DADF to copolymer VP-VS 70:30 have the best physical and mechanical properties in a series (σ = 11,5 MPa, ε = 76%). The introduction of the resulting polymer materials lysozyme leads to increased strength at break from 43% to 97%.The thermophysical properties of PUS depend on the presence of lysozyme in their composition.When introducing into the structure PUS of the enzyme , an increase in the glass transition temperature and a decrease in the heat capacity jump due to the decrease in the segmental mobility of the macromolecules. It is established that the studied systems are single-phase.The method of culture of tissues was founding that all composite materials are biocompatible and non-toxic. For experimental samples with lysozyme, more active growth of fibroblast cells was observed.
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