| Autor: |
Fei Chen, Xin-Miao Wang, Xin Huang |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Frontiers in Neuroscience, Vol 18 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1662-453X |
| DOI: |
10.3389/fnins.2024.1458897 |
| Popis: |
ObjectiveAn increasing amount of neuroimaging evidence indicates that patients with anterior segment ischemic optic neuropathy (AION) exhibit abnormal brain function and structural architecture. Some studies have shown that there are abnormal functional and structural changes in the brain visual area of AION patients. Nevertheless, the alterations in the topological properties of brain functional connectivity among patients with AION remain unclear. This study aimed to investigate the topological organization of brain functional connectivity in a group of AION patients using graph theory methods.MethodsResting-state magnetic resonance imaging was conducted on 30 AION patients and 24 healthy controls (HCs) matched for age, gender, and education level. For each participant, a high-resolution brain functional network was constructed using time series correlation and quantified through graph theory analysis.ResultsBoth the AION and HC groups presented high-efficiency small-world networks in their brain functional networks. In comparison to the HCs, the AION group exhibited notable reductions in clustering coefficient (Cp) and local efficiency (Eloc). Specifically, significant decreases in Nodal local efficiency were observed in the right Amygdala of the AION group. Moreover, the NBS method detected a significantly modified network (15 nodes, 15 connections) in the AION group compared to the HCs (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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