| Autor: |
Gabriela Cavalcante da Silva, Alisson Macário de Oliveira, Wêndeo Kennedy Costa, Antônio Felix da Silva Filho, Maira Galdino da Rocha Pitta, Moacyr Jesus Barreto de Melo Rêgo, Ivone Antônia de Souza, Patrícia Maria Guedes Paiva, Thiago Henrique Napoleão |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Current Research in Pharmacology and Drug Discovery, Vol 3, Iss , Pp 100093- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2590-2571 |
| DOI: |
10.1016/j.crphar.2022.100093 |
| Popis: |
The rhizome of Microgramma vacciniifolia contains a lectin (carbohydrate-binding protein) called MvRL. Studies demonstrated that a MvRL-rich fraction did not show in vivo genotoxicity and acute toxicity in mice. This study aimed to evaluate the MvRL-rich fraction from M. vacciniifolia rhizome for antibacterial activity in vitro and in vivo as well as antitumor effect in vivo using the Ehrlich carcinoma model in mice. The fraction showed antibacterial activity against Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus with minimal inhibitory concentrations ranging from 31.2 to 125.0 μg/mL and minimal bactericidal concentrations from 62.5 to 200 μg/mL. The fraction was also effective in vivo against infection caused by these bacteria on Tenebrio molitor larvae considering the parameters evaluated. In regard to the antitumor activity, the treatments of Ehrlich carcinoma-bearing mice with the fraction at 100 and 200 mg/kg per os resulted in 62.58% and 75.43% of tumor inhibition, respectively. In conclusion, the MvRL-rich fraction showed in vivo antibacterial and antitumor activities and thus can be considered as an alternative of natural origin for the development of candidates for therapy. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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