Pathogenesis of Takotsubo syndrome
| Autor: | Daniele Masarone, Valeria Maddaloni, Marta Rubino, Fiorella Fratta, Annapaola Cirillo, Ludovica Spinelli Barrile, Roberta Pacileo, Adelaide Fusco, Guido Coppola, Francesca Pisacane, Paolo Calabrò, Raffaele Calabrò, Edoardo Bossone, Maria Giovanna Russo, Giuseppe Pacileo |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Cardiogenetics, Vol 6, Iss 1 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2035-8253 2035-8148 |
| DOI: | 10.4081/cardiogenetics.2016.5973 |
| Popis: | Takotsubo syndrome (TTS) is an enigmatic disease with a multifactorial and still unresolved pathogenesis. Postulated mechanisms include catecholamine excess, coronary artery spasm, and microvascular dysfunction, however catecholamines seem to play a central role in the pathophysiology of TTS. In facts catecholamines have relevant effects on the vasculature and myocardium. Toxic direct effects of catecholamine on myocardium are mediated by multiple pathway including functional hypoxia, metabolic changes and changes in membrane permeability leading to various electrolytic imbalances. Recently report of familial cases has suggested a genetic component. Further research is required to help clarify the proposed hypotheses and to increase our understanding of the cardiovascular responses to acute stress and the pathophysiology underpinning TTS. |
| Databáze: | Directory of Open Access Journals |
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